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Alterations of Phosphodiesterases in Adrenocortical Tumors

30 Aug 2016

Abstract excerpt

Alterations in the cyclic (c)AMP-dependent signaling pathway have been implicated in the majority of benign adrenocortical tumors (ACTs) causing Cushing syndrome (CS). Phosphodiesterases (PDEs) are enzymes that regulate cyclic nucleotide levels, including cyclic adenosine monophosphate (cAMP). Inactivating mutations and other functional variants in PDE11A and PDE8B, two cAMP-binding PDEs, predispose to ACTs. The...

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PMID: 27625633
DOI: 10.3389/fendo.2016.00111

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