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Article

Associations of TIMP-3 Genetic Polymorphisms with EGFR Statuses and Cancer Clinicopathologic Development in Lung Adenocarcinoma Patients.

International journal of molecular sciences - 28 Oct 2020

Chang Jer-Hwa, Lai Tsung-Ching, Yang Po-Jen, Shih Pei-Chun, Yang Yi-Chieh, Lee Kai-Ling, Liu Tu-Chen, Tsao Thomas Chang-Yao, Yang Shun-Fa, Chien Ming-Hsien

Abstract excerpt

Lung adenocarcinoma (LADC) is a major subtype of lung cancer, particularly among populations of East Asia. The epidermal growth factor receptor (EGFR) is the most frequently mutated oncogene promoting LADC progression and can serve as a therapeutic target in LADC. The tissue inhibitor of metalloproteinases (TIMP)-3 is a major regulator of extracellular matrix turnover via targeting of matrix metalloproteinases...

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Identifiers

PMID: 33126605
DOI: 10.3390/ijms21218023
PMCID: PMC7662501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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