Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Strong Decrease in TIMP3 Expression Mediated by the Presence of miR-17 and 20a Enables Extracellular Matrix Remodeling in the NSCLC Lesion Surroundings

13 Dec 2019

Abstract excerpt

Lung cancer is one of the most common causes of death worldwide with a relatively high fatality rate and a mean 5-year survival of about 18%. One of the hallmarks of cancer is the extracellular matrix (ECM) remodelling, which is crucial for metastasis. This process may be regulated by miRs targeting metalloproteinases (MMPs) associated with the ECM breakdown and metastatic process or blocking the action of tissue...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to MicroRNA in disease regulation
Share to Peptidase Inhibition and Analysis
Share to Protease and Inhibitor Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31921636
DOI: 10.3389/fonc.2019.01372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Strong Decrease in TIMP3 Expression Mediated by the Presence of miR-17 and 20a Enables Extracellular Matrix Remodeling in the NSCLC Lesion SurroundingsPMID 31921636Read ↗

Matrix Metalloproteinase-19 Promotes Metastatic Behavior <i>In Vitro</i> and is Associated with Increased Mortality in Non–Small Cell Lung CancerSemantic proximity Read ↗

Matrix Metalloproteinases and Their Inhibitors in Chronic Obstructive Pulmonary Disease.Semantic proximity Read ↗

A Comprehensive Bioinformatics Analysis of TIMP2 in Multiple MalignanciesSemantic proximity Read ↗

Quantitative proteomics identifies tumour matrisome signatures in patients with non-small cell lung cancerSemantic proximity Read ↗

Associations of TIMP-3 Genetic Polymorphisms with EGFR Statuses and Cancer Clinicopathologic Development in Lung Adenocarcinoma Patients.Semantic proximity Read ↗

The inhibitory effect of M2 macrophage-derived exosomes on gefitinib resistant lung adenocarcinoma cells through the MIF/TIMP1/CD74 axisSemantic proximity Read ↗

Relevant MicroRNAs of MMPs and TIMPs with Certain Gut Microbiota Could Be Involved in the Invasiveness and Metastasis of Malignant TumorsSemantic proximity Read ↗

ADAM17 is overexpressed in non-small cell lung cancer and its expression correlates with poor patient survivalSemantic proximity Read ↗

An integrative analysis reveals the prognostic and immunological role of TIMP gene family in pan-cancerSemantic proximity Read ↗

Tumor-derived exosomal miR-21-5p mediates lung fibroblasts activation via TNFAIP3/NF-kB signaling to promote non-small cell lung cancer cell migration and invasionSemantic proximity Read ↗

Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state.Semantic proximity Read ↗

The incorporation of acetylated LAP-TGF-β1 proteins into exosomes promotes TNBC cell dissemination in lung micro-metastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.