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Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.

Stem cell reports - 9 Oct 2018

Kauts Mari-Liis, De Leo Bianca, Rodríguez-Seoane Carmen, Ronn Roger, Glykofrydis Fokion, Maglitto Antonio, Kaimakis Polynikis, Basi Margarita, Taylor Helen, Forrester Lesley, Wilkinson Adam C, Göttgens Berthold, Saunders Philippa, Dzierzak Elaine

Abstract excerpt

Mast cells are tissue-resident immune cells. Their overgrowth/overactivation results in a range of common distressing, sometimes life-threatening disorders, including asthma, psoriasis, anaphylaxis, and mastocytosis. Currently, drug discovery is hampered by use of cancer-derived mast cell lines or primary cells. Cell lines provide low numbers of mature mast cells and are not representative of in vivo mast cells....

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Identifiers

PMID: 30197119
DOI: 10.1016/j.stemcr.2018.08.007
PMCID: PMC6178197

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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