RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer.

doi:10.1038/s41419-020-03131-3

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Article

RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer.

Cell death & disease - 29 Oct 2020

Khawaja Hajrah, Campbell Andrew, Roberts Jamie Z, Javadi Arman, O'Reilly Paul, McArt Darragh, Allen Wendy L, Majkut Joanna, Rehm Markus, Bardelli Alberto, Di Nicolantonio Federica, Scott Christopher J, Kennedy Richard, Vitale Nicolas, Harrison Timothy, Sansom Owen J, Longley Daniel B, Evergren Emma, Van Schaeybroeck Sandra

Abstract excerpt

RAS mutant (MT) metastatic colorectal cancer (mCRC) is resistant to MEK1/2 inhibition and remains a difficult-to-treat group. Therefore, there is an unmet need for novel treatment options for RASMT mCRC. RALA and RALB GTPases function downstream of RAS and have been found to be key regulators of several cell functions implicated in KRAS-driven tumorigenesis. However, their role as regulators of the apoptotic...

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PMID: 33122623
DOI: 10.1038/s41419-020-03131-3
PMCID: PMC7596570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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