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Article

Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling.

The Journal of biological chemistry - 2 Jan 2012

Oh You-Take, Yue Ping, Zhou Wei, Balko Justin M, Black Esther P, Owonikoko Taofeek K, Khuri Fadlo R, Sun Shi-Yong

Abstract excerpt

Oncogenic mutations of ras and B-raf frequently occur in many cancer types and are critical for cell transformation and tumorigenesis. Death receptor 5 (DR5) is a cell surface pro-apoptotic death receptor for tumor necrosis factor-related apoptosis-inducing ligand and has been targeted in cancer...

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Identifiers

PMID: 22065586
DOI: 10.1074/jbc.M111.304006
PMCID: PMC3249076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22065586-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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