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Article

Association of AIRE (rs2075876), but not CTLA4 (rs231775) polymorphisms with systemic lupus erythematosus.

Gene - 5 Feb 2021

Alghamdi Saleh A, Kattan Shahad W, Toraih Eman A, Alrowaili Majed G, Fawzy Manal S, Elshazli Rami M

Abstract excerpt

BACKGROUND: The AIRE (rs2075876) and CTLA4 (rs231775) variants have a crucial function in controlling the negative selection and suppression of T lymphocytes. Numerous reports studied the association of AIRE and CTLA4 variants with different autoimmune disorders, but with inconclusive conclusions. The main purpose of this work is to evaluate the association of these two variants with SLE susceptibility among...

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Identifiers

PMID: 33122082
DOI: 10.1016/j.gene.2020.145270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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