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Article

Association between AIRE gene polymorphism and rheumatoid arthritis: a systematic review and meta-analysis of case-control studies.

Scientific reports - 26 Oct 2017

Bérczi Bálint, Gerencsér Gellért, Farkas Nelli, Hegyi Péter, Veres Gábor, Bajor Judit, Czopf László, Alizadeh Hussain, Rakonczay Zoltán, Vigh Éva, Erőss Bálint, Szemes Kata, Gyöngyi Zoltán

Abstract excerpt

Autoimmune regulator (AIRE) is a transcription factor that functions as a novel player in immunological investigations. In the thymus, it has a pivotal role in the negative selection of naive T-cells during central tolerance. Experimental studies have shown that single nucleotide polymorphism (SNP) alters transcription of the AIRE gene. SNPs thereby provide a less efficient negative selection, propagate higher...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29074995
DOI: 10.1038/s41598-017-14375-z
PMCID: PMC5658331

Genes

AIRE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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