Article
A Multiancestry Sex-Stratified Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus.
The Journal of infectious diseases - 15 Jun 2021
Vergara Candelaria, Valencia Ana, Thio Chloe L, Goedert James J, Mangia Alessandra, Piazzolla Valeria, Johnson Eric, Kral Alex H, O'Brien Thomas R, Mehta Shruti H, Kirk Gregory D, Kim Arthur Y, Lauer Georg M, Chung Raymond T, Cox Andrea L, Peters Marion G, Khakoo Salim I, Alric Laurent, Cramp Matthew E, Donfield Sharyne M, Edlin Brian R, Busch Michael P, Alexander Graeme, Rosen Hugo R, Murphy Edward L, Wojcik Genevieve L, Taub Margaret A, Thomas David L, Duggal Priya
Abstract excerpt
BACKGROUND: Spontaneous clearance of acute hepatitis C virus (HCV) infection is more common in women than in men, independent of known risk factors. METHODS: To identify sex-specific genetic loci, we studied 4423 HCV-infected individuals (2903 male, 1520 female) of European, African, and Hispanic ancestry. We performed autosomal, and X chromosome sex-stratified and combined association analyses in each ancestry...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.