Article
Induced, but not natural, regulatory T cells retain phenotype and function following exposure to inflamed synovial fibroblasts.
Science advances - 1 Oct 2020
Yang Sujuan, Zhang Ximei, Chen Jingrong, Dang Junlong, Liang Rongzhen, Zeng Donglan, Zhang Huan, Xue Youqiu, Liu Yan, Wu Wenbin, Zhao Jun, Wang Julie, Pan Yunfeng, Xu Hanshi, Sun Bing, Huang Feng, Lu Yan, Hsueh Willa, Olsen Nancy, Zheng Song Guo
Abstract excerpt
Aberrant number and/or dysfunction of CD4+Foxp3+ Regulatory T cells (Tregs) are associated with the pathogenesis of rheumatoid arthritis (RA). A previous study has demonstrated that thymus-derived, natural Tregs (nTregs) prefer to accumulate in inflamed joints and transdifferentiate to TH17 cells under the stimulation of inflamed synovial fibroblasts (SFs). In this study, we made a head-to-head comparison of both...
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