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Article

Exosomal miR-146a Contributes to the Enhanced Therapeutic Efficacy of Interleukin-1β-Primed Mesenchymal Stem Cells Against Sepsis.

Stem cells (Dayton, Ohio) - 1 May 2017

Song Yuxian, Dou Huan, Li Xiujun, Zhao Xiaoyin, Li Yi, Liu Dan, Ji Jianjian, Liu Fei, Ding Liang, Ni Yanhong, Hou Yayi

Abstract excerpt

Improving the immunomodulatory efficacy of mesenchymal stem cells (MSCs) through pretreatment with pro-inflammatory cytokines is an evolving field of investigation. However, the underlying mechanisms have not been fully clarified. Here, we pretreated human umbilical cord-derived MSCs with interleukin-1β (IL-1β) and evaluated their therapeutic effects in a cecal ligation and puncture-induced sepsis model. We found...

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PMID: 28090688
DOI: 10.1002/stem.2564

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