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Article

Aging-Related Phenotypic Conversion of Medullary Microglia Enhances Intraoral Incisional Pain Sensitivity.

International journal of molecular sciences - 23 Oct 2020

Ikutame Daisuke, Urata Kentaro, Oto Tatsuki, Fujiwara Shintaro, Iinuma Toshimitsu, Shibuta Ikuko, Hayashi Yoshinori, Hitomi Suzuro, Iwata Koichi, Shinoda Masamichi

Abstract excerpt

Activated microglia involved in the development of orofacial pain hypersensitivity have two major polarization states. The aim of this study was to assess the involvement of the aging-related phenotypic conversion of medullary microglia in the enhancement of intraoral pain sensitivity using senescence-accelerated mice (SAM)-prone/8 (SAMP8) and SAM-resistant/1 (SAMR1) mice. Mechanical head-withdrawal threshold...

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Identifiers

PMID: 33114176
DOI: 10.3390/ijms21217871
PMCID: PMC7660637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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