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Article

Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B.

EBioMedicine - 1 Nov 2020

Liu Kefu, Zhao Juan, Chen Chunnuan, Xu Jie, Bell Richard L, Hall Frank S, Koob George F, Volkow Nora D, Qing Hong, Lin Zhicheng

Abstract excerpt

BACKGROUND: Slow neurotransmission including DARPP-32 signalling is implicated in substance use disorders (SUDs) by experimental systems but not yet in the human aetiology. PPP1R12B, encoding another protein in the DARPP-32 family, hasn't been studied in the brain. METHODS: Brain-regional gene activity was assessed in three different animal models of SUDs for mRNA level alterations. Genetic associations were...

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Share to Dopamine and cAMP-Regulated Phosphoprotein 32
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33096475
DOI: 10.1016/j.ebiom.2020.103066
PMCID: PMC7581882

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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