Article
DRD2 and PPP1R1B (DARPP-32) polymorphisms independently confer increased risk for autism spectrum disorders and additively predict affected status in male-only affected sib-pair families.
Behavioral and brain functions : BBF - 4 May 2012
Hettinger Joe A, Liu Xudong, Hudson Melissa L, Lee Alana, Cohen Ira L, Michaelis Ron C, Schwartz Charles E, Lewis Suzanne M E, Holden Jeanette J A
Abstract excerpt
BACKGROUND: The neurotransmitter dopamine (DA) modulates executive functions, learning, and emotional processing, all of which are impaired in individuals with autism spectrum disorders (ASDs). Our previous findings suggest a role for dopamine-related genes in families with only affected males. METHODS: We examined two additional genes which affect DA function, the DRD2 and PPP1R1B (DARPP-32) genes, in a cohort...
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