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Article

Rare genetic forms of obesity: From gene to therapy.

Physiology & behavior - 1 Dec 2020

Clément K, Mosbah H, Poitou C

Abstract excerpt

Monogenic non-syndromic obesity is characterized by severe early-onset obesity with abnormal eating behaviour and endocrine disorders. Genes contributing to these rare forms of obesity are mainly located in the leptin/melanocortin pathway, with typically an autosomal additive inheritance of obesity. The normal function of this hypothalamic pathway is essential for the control of energy balance. Genetic variants...

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PMID: 32805220
DOI: 10.1016/j.physbeh.2020.113134

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