Article
A <i>TREM2</i> -derived circRNA is upregulated in the entorhinal cortex of Alzheimer’s disease patients
2021-06-23
Abstract excerpt
Circular RNAs (circRNAs) are a novel class of noncoding RNAs characterized by a covalent and stable closed loop structure. circRNAs are enriched in neural tissues, particularly at synapses, where they are involved in synaptic plasticity. Alzheimer’s disease (AD) is considered a synaptopathy since neurodegeneration causes loss or dysfunction of synapses. Microglia participate in synaptic pruning and also play a cru...
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Identifiers and source
- Literature Corpus work
- f07226b4-c62a-5fad-a5e9-e6d65c93debf
- DOI
- 10.1101/2021.06.23.449571