Article
Smoking-related changes in DNA methylation and gene expression are associated with cardio-metabolic traits.
Clinical epigenetics - 22 Oct 2020
Maas Silvana C E, Mens Michelle M J, Kühnel Brigitte, van Meurs Joyce B J, Uitterlinden André G, Peters Annette, Prokisch Holger, Herder Christian, Grallert Harald, Kunze Sonja, Waldenberger Melanie, Kavousi Maryam, Kayser Manfred, Ghanbari Mohsen
Abstract excerpt
BACKGROUND: Tobacco smoking is a well-known modifiable risk factor for many chronic diseases, including cardiovascular disease (CVD). One of the proposed underlying mechanism linking smoking to disease is via epigenetic modifications, which could affect the expression of disease-associated genes. Here, we conducted a three-way association study to identify the relationship between smoking-related changes in DNA...
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