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Article

SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes.

Nature communications - 11 May 2021

Jungreis Irwin, Sealfon Rachel, Kellis Manolis

Abstract excerpt

Despite its clinical importance, the SARS-CoV-2 gene set remains unresolved, hindering dissection of COVID-19 biology. We use comparative genomics to provide a high-confidence protein-coding gene set, characterize evolutionary constraint, and prioritize functional mutations. We select 44 Sarbecovirus genomes at ideally-suited evolutionary distances, and quantify protein-coding evolutionary signatures and...

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Identifiers

PMID: 33976134
DOI: 10.1038/s41467-021-22905-7
PMCID: PMC8113528

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