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Emergence of SARS-CoV-2 through recombination and strong purifying selection

29 May 2020

Abstract excerpt

COVID-19 has become a global pandemic caused by the novel coronavirus SARS-CoV-2. Understanding the origins of SARS-CoV-2 is critical for deterring future zoonosis, discovering new drugs, and developing a vaccine. We show evidence of strong purifying selection around the receptor binding motif (RBM) in the spike and other genes among bat, pangolin, and human coronaviruses, suggesting similar evolutionary...

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PMID: 32937441
DOI: 10.1126/sciadv.abb9153

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