Article
Genetic and Chemical Screening in Human Blood Serum Reveals Unique Antibacterial Targets and Compounds against Klebsiella pneumoniae.
Cell reports - 21 Jul 2020
Weber Brent S, De Jong Aaron M, Guo Amelia B Y, Dharavath Srinivas, French Shawn, Fiebig-Comyn Aline A, Coombes Brian K, Magolan Jakob, Brown Eric D
Abstract excerpt
Antibiotics halt the growth of bacteria by targeting core, essential physiology that is required for life on standard microbiological media. Many more biochemical and virulence processes, however, are required for bacteria to cause infection in a host. Indeed, chemical inhibitors of the latter processes are overlooked using conventional antibiotic drug discovery approaches. Here, we use human blood serum as an...
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