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Article

Identification of MMP14 and MKLN1 as colorectal cancer susceptibility genes and drug-repositioning candidates from a genome-wide association study.

Journal of translational medicine - 14 May 2025

Yun Dabin, Yang Jung-Ho, Sim Jin-Ah, Kim Minjung, Park Ji Won, Jeong Seung Yong, Shin Aesun, Kweon Sun-Seog, Song Nan

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) and subsequent functional interpretation have been used to identify susceptible genes and potential drug-repositioning candidates. This study aimed to identify genes associated with colorectal cancer (CRC) and potential drug-repositioning candidates. METHODS: Patients with CRC at Seoul National University Hospital (SNUH, discovery study) and Chonnam National...

Read the complete abstract on PubMed

Topics

Humans
Colorectal Neoplasms
Genome-Wide Association Study
Male
Female
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Polymorphism, Single Nucleotide

Case-Control Studies

Microfilament Proteins

Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 40369569
DOI: 10.1186/s12967-025-06491-6
PMCID: PMC12079816

Genes

MMP14
MKLN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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