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Novel genetically stable infectious clone for a Zika virus clinical isolate and identification of RNA elements essential for virus production.

Virus research - 15 Sept 2018

Chen Yiyi, Liu Ting, Zhang Zhenzhen, Chen Mingxiao, Rong Liang, Ma Ling, Yu Bolan, Wu De, Zhang Ping, Zhu Xun, Huang Xi, Zhang Hui, Li Yi-Ping

Abstract excerpt

Zika virus (ZIKV) is an Aedes mosquitoes-transmitted flavivirus, and its infection may cause severe neurological diseases. A genetically stable infectious clone is essential for ZIKV research, however the toxicity and instability of the viral cDNA in bacteria potentially due to its bacterial promoter activity are major challenges. Here, we constructed a full-length cDNA clone for isolate ZG01 by introducing...

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PMID: 30144463
DOI: 10.1016/j.virusres.2018.08.016

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