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Article

M2 Macrophage-Derived Exosomal miR-590-3p Attenuates DSS-Induced Mucosal Damage and Promotes Epithelial Repair via the LATS1/YAP/ β-Catenin Signalling Axis.

Journal of Crohn's & colitis - 6 Apr 2021

Deng Feihong, Yan Jin, Lu Jiaxi, Luo Min, Xia Pianpian, Liu Siliang, Wang Xuehong, Zhi Fachao, Liu Deliang

Abstract excerpt

BACKGROUND AND AIMS: M2 phenotype macrophages are involved in the resolution of inflammation and intestinal repair. Exosomes are emerging as important mediators of intercellular communication in the mucosal microenvironment. METHODS: M2 macrophages were transfected with or without miR-590-3p. Exosomes derived from M2 macrophages were isolated and identified. Proliferation and wound healing were tested in vitro...

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PMID: 33075119
DOI: 10.1093/ecco-jcc/jjaa214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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