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Article

Novel roles of GATA1 in regulation of angiogenic factor AGGF1 and endothelial cell function.

The Journal of biological chemistry - 28 Aug 2009

Fan Chun, Ouyang Ping, Timur Ayse A, He Ping, You Sun-Ah, Hu Ying, Ke Tie, Driscoll David J, Chen Qiuyun, Wang Qing Kenneth

Abstract excerpt

AGGF1 is an angiogenic factor, and its deregulation is associated with a vascular malformation consistent with Klippel-Trenaunay syndrome (KTS). This study defines the molecular mechanism for transcriptional regulation of AGGF1 expression. Transcription of AGGF1 starts at two nearby sites, -367 and -364 bp upstream of the translation start site. Analyses of 5'- and 3'-serial promoter deletions defined the core...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19556247
DOI: 10.1074/jbc.M109.036079
PMCID: PMC2749107

Genes

AGGF1
GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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