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Article

Inflammation and Oxidative-Stress Pathways Are Associated with Idiopathic Sudden Hearing Loss: A Genome-Wide Association Study in 15,494 Japanese Individuals.

International journal of molecular sciences - 14 Feb 2026

Kitoh Ryosuke, Nishio Shin-Ya, Takumi Yutaka, Usami Shin-Ichi

Abstract excerpt

The etiology of idiopathic sudden sensorineural hearing loss (iSSNHL) remains unclear, and genome-wide genetic evidence is limited. We conducted a multicenter Japanese case-control genome-wide association study including 192 clinically defined iSSNHL cases and 15,302 controls aged ≥80 years without a history of hearing loss. After cross-platform SNP harmonization and imputation (Eagle/Minimac4), association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41751972
DOI: 10.3390/ijms27041836
PMCID: PMC12941261

Genes

FHIT
MEGF10
TRMT1L
ID4
LHX2
MYT1L
RNF2
SAMD5
SPATS1
SWT1
TAPBPL
VAMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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