Article
Non-invasive detection of EGFR mutations by cell-free loop-mediated isothermal amplification (CF-LAMP).
Scientific reports - 16 Oct 2020
Arjuna Srividya, Venkataram Rajesh, Dechamma Pandyanda Nanjappa, Chakraborty Gunimala, Babu Nishith, D'Cruz Audrey, Hosmane Giridhar Belur, Chakraborty Anirban
Abstract excerpt
Targeting epidermal growth factor receptor (EGFR) through tyrosine kinase inhibitors (TKI) is a successful therapeutic strategy in non-small cell lung cancer. However, the response to TKI therapy depends on specific activating and acquired mutations in the tyrosine kinase domain of the EGFR gene. Therefore, confirming the EGFR status of patients is crucial, not only for determining the eligibility, but also for...
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