Article
Detection of EGFR Gene Mutation by Mutation-oriented LAMP Method.
Anticancer research - 1 Apr 2018
Matsumoto Naoyuki, Kumasaka Akira, Ando Tomohiro, Komiyama Kazuo
Abstract excerpt
BACKGROUND/AIM: Epidermal growth factor receptor (EGFR) is a target of molecular therapeutics for non-small cell lung cancer. EGFR gene mutations at codons 746-753 promote constitutive EGFR activation and result in worst prognosis. However, these mutations augment the therapeutic effect of EGFR-tyrosine kinase inhibitor. Therefore, the detection of EGFR gene mutations is important for determining treatment...
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