Shift toward T lymphocytes with a T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis.

doi:10.1002/art.1780391204

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Article

Shift toward T lymphocytes with a T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis.

Arthritis and rheumatism - 1 Dec 1996

Dolhain R J, van der Heiden A N, ter Haar N T, Breedveld F C, Miltenburg A M

Abstract excerpt

OBJECTIVE: To investigate whether T cells in the inflamed joints of patients with rheumatoid arthritis (RA) preferentially produce the T helper 1 (Th1) cytokines, interferon-gamma (IFN gamma) and interleukin-2 (IL-2), or the Th2 cytokine, IL-4, when compared with corresponding peripheral blood-derived T cells. METHODS: Synovial fluid mononuclear cells (SFMC) and corresponding peripheral blood mononuclear cells...

Topics

Arthritis, Rheumatoid
CD3 Complex
CD4 Antigens
Cytokines
Humans
Interferon-gamma
Interleukin-2
Interleukin-4
Leukocytes, Mononuclear
Monocytes
Phenotype
Synovial Fluid
Th1 Cells
Th2 Cells

Source

Open in PubMed

Identifiers

PMID: 8961900
DOI: 10.1002/art.1780391204

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