Article
Cytotoxicity and Mitochondrial Dysregulation Caused by α-Synuclein in Dictyostelium discoideum.
Cells - 14 Oct 2020
Fernando Sanjanie, Allan Claire Y, Mroczek Katelyn, Pearce Xavier, Sanislav Oana, Fisher Paul R, Annesley Sarah J
Abstract excerpt
Alpha synuclein has been linked to both sporadic and familial forms of Parkinson's disease (PD) and is the most abundant protein in Lewy bodies a hallmark of Parkinson's disease. The function of this protein and the molecular mechanisms underlying its toxicity are still unclear, but many studies have suggested that the mechanism of α-synuclein toxicity involves alterations to mitochondrial function. Here we...
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