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Article

Genetic suppressor of autophagy defects in huntingtin null cells identified using a mutagenesis screen in Dictyostelium discoideum.

BMC molecular and cell biology - 2 Feb 2026

Cuoco Lauren, Gill Shelbi E, Francois Luc, Souders Sarah, DeMasi Caroline, Moore Jeffrey R, Chain Frédéric J J

Abstract excerpt

BACKGROUND: Huntingtin (HTT) is an important gene for cellular processes such as autophagy, and its loss leads to neurodegenerative disease phenotypes. In Dictyostelium discoideum, HTT-null (htt-) cells exhibit impaired basal autophagy and fail to develop in the presence of ammonium chloride. RESULTS: Here we conducted a mutagenesis screen on htt- cells to identify potential genetic suppressors of the htt-...

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PMID: 41629784
DOI: 10.1186/s12860-026-00570-2
PMCID: PMC12954983

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HTT

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