Article
A single intradermal injection of IFN-γ induces an inflammatory state in both non-lesional psoriatic and healthy skin.
The Journal of investigative dermatology - 1 Apr 2012
Johnson-Huang Leanne M, Suárez-Fariñas Mayte, Pierson Katherine C, Fuentes-Duculan Judilyn, Cueto Inna, Lentini Tim, Sullivan-Whalen Mary, Gilleaudeau Patricia, Krueger James G, Haider Asifa S, Lowes Michelle A
Abstract excerpt
Psoriasis is a chronic, debilitating, immune-mediated inflammatory skin disease. As IFN-γ is involved in many cellular processes, including activation of dendritic cells (DCs), antigen processing and presentation, cell adhesion and trafficking, and cytokine and chemokine production, IFN-γ-producing Th1 cells were proposed to be integral to the pathogenesis of psoriasis. Recently, IFN-γ was shown to enhance IL-23...
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