Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of hepatic macrophages and evaluation of inflammatory response in heme oxygenase-1 deficient mice exposed to scAAV9 vectors.

PloS one - 1 Jan 2020

Tomczyk Mateusz, Kraszewska Izabela, Mąka Robert, Waligórska Agnieszka, Dulak Józef, Jaźwa-Kusior Agnieszka

Abstract excerpt

Adeno-associated viral (AAV) vectors are characterised by low immunogenicity, although humoral and cellular responses may be triggered upon infection. Following systemic administration high levels of vector particles accumulate within the liver. Kupffer cells (KCs) are liver resident macrophages and an important part of the liver innate immune system. Decreased functional activity of KCs can contribute to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokine CCL2
Share to Dependovirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Vectors

Share to Heme Oxygenase-1

Share to Interleukin-6

Share to Kupffer Cells

Share to Toll-Like Receptor 9

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 33057437
DOI: 10.1371/journal.pone.0240691
PMCID: PMC7561190

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of hepatic macrophages and evaluation of inflammatory response in heme oxygenase-1 deficient mice exposed to scAAV9 vectors.PMID 33057437Read ↗

The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9–dependent innate immune responses in the liverSemantic proximity Read ↗

3D co-cultures of primary human hepatocytes and Kupffer-like cells to address innate immune responses to rAAVSemantic proximity Read ↗

Generation and functional characterization of a clonal murine periportal Kupffer cell line from H-2Kb -tsA58 mice.Semantic proximity Read ↗

Availability of an inflammatory macrophage niche drives phenotypic and functional alterations in Kupffer cellsSemantic proximity Read ↗

Two Key Challenges for Effective Adenovirus-Mediated Liver Gene Therapy:Innate Immune Responses and Hepatocyte-Specific TransductionSemantic proximity Read ↗

Development of a cytokine-producing immortalized murine Kupffer cell line.Semantic proximity Read ↗

AAV Vectors Avoid Inflammatory Signals Necessary to Render Transduced Hepatocyte Targets for Destructive T CellsSemantic proximity Read ↗

Analysis of Adenovirus Sequestration in the Liver, Transduction of Hepatic Cells, and Innate Toxicity after Injection of Fiber-Modified VectorsSemantic proximity Read ↗

Macrophage inhibitor clodronate enhances liver transduction of lentiviral but not AAV vectors or mRNA lipid nanoparticles <i>in vivo</i>Semantic proximity Read ↗

Monitoring liver macrophages using nanobodies targeting Vsig4: concanavalin A induced acute hepatitis as paradigm.Semantic proximity Read ↗

Hepatocytes trap and silence coxsackieviruses, protecting against systemic disease in miceSemantic proximity Read ↗

CRIg mediates early Kupffer cell responses to adenovirusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.