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Article

Variant ranking pipeline for complex familial disorders.

Scientific reports - 13 Jun 2024

Ralli Sneha, Vira Tariq, Robles-Espinoza Carla Daniela, Adams David J, Brooks-Wilson Angela R

Abstract excerpt

Identifying genetic susceptibility factors for complex disorders remains a challenging task. To analyze collections of small and large pedigrees where genetic heterogeneity is likely, but biological commonalities are plausible, we have developed a weights-based pipeline to prioritize variants and genes. The Weights-based vAriant Ranking in Pedigrees (WARP) pipeline prioritizes variants using 5 weights: disease...

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Identifiers

PMID: 38866901
DOI: 10.1038/s41598-024-64169-3
PMCID: PMC11169219

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