Article
Integrated Analysis of Coexpression and Exome Sequencing to Prioritize Susceptibility Genes for Familial Cutaneous Melanoma.
The Journal of investigative dermatology - 1 Sept 2022
Yepes Sally, Tucker Margaret A, Koka Hela, Xiao Yanzi, Zhang Tongwu, Jones Kristine, Vogt Aurelie, Burdette Laurie, Luo Wen, Zhu Bin, Hutchinson Amy, Yeager Meredith, Hicks Belynda, Brown Kevin M, Freedman Neal D, Chanock Stephen J, Goldstein Alisa M, Yang Xiaohong R
Abstract excerpt
The application of whole-exome sequencing has led to the identification of high- and moderate-risk variants that contribute to cutaneous melanoma susceptibility. However, confirming disease-causing variants remains challenging. We applied a gene coexpression network analysis to prioritize the candidate genes identified from whole-exome sequencing of 34 melanoma-prone families, with at least three affected members...
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