Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A genome-wide CRISPR screening uncovers that TOB1 acts as a key host factor for FMDV infection via both IFN and EGFR mediated pathways

21 Mar 2024

Abstract excerpt

The interaction between foot-and-mouth disease virus (FMDV) and the host is extremely important for virus infection, but there are few researches on it, which is not conducive to vaccine development and FMD control. In this study, we designed a porcine genome-scale CRISPR/Cas9 knockout library containing 93,859 single guide RNAs targeting 16,886 protein-coding genes, 25 long ncRNAs, and 463 microRNAs. Using this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Disease Management and Epidemiology
Share to interferon and immune responses
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38512977
DOI: 10.1371/journal.ppat.1012104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genome-wide CRISPR screening uncovers that TOB1 acts as a key host factor for FMDV infection via both IFN and EGFR mediated pathwaysPMID 38512977Read ↗

Multiplex CRISPR strategy targeting viral genome for agriculture and clinical useSemantic proximity Read ↗

Multiplex CRISPR strategy targeting viral genome for agriculture and clinical useSemantic proximity Read ↗

CRISPR screening of porcine sgRNA library identifies host factors associated with Japanese encephalitis virus replicationSemantic proximity Read ↗

Genome Editing Strategies to Protect Livestock from Viral InfectionsSemantic proximity Read ↗

Identification of host factors for livestock and poultry viruses: genome-wide screening technology based on the CRISPR systemSemantic proximity Read ↗

Genome-wide CRISPR/Cas9 screen identifies host factors for Newcastle disease virus replicationSemantic proximity Read ↗

A genome-wide CRISPR/Cas9 knockout screen identifies TMEM239 as an important host factor in facilitating African swine fever virus entry into early endosomesSemantic proximity Read ↗

RNA-Seq based transcriptome analysis during bovine viral diarrhoea virus (BVDV) infectionSemantic proximity Read ↗

Identification of the role of RIG-I, MDA-5 and TLR3 in sensing RNA viruses in porcine epithelial cells using lentivirus-driven RNA interferenceSemantic proximity Read ↗

CRISPR screening of porcine sgRNA library identified host factors essential for Japanese encephalitis virus replicationSemantic proximity Read ↗

Testing multiplexed anti-ASFV CRISPR-Cas9 in reducing African swine fever virusSemantic proximity Read ↗

Identification of key host genes for influenza A virus in avian cells using a genome-wide CRISPR-Cas9 screenSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.