Article
Association of age at diagnosis and genetic mutations in patients with neuroblastoma.
JAMA - 14 Mar 2012
Cheung Nai-Kong V, Zhang Jinghui, Lu Charles, Parker Matthew, Bahrami Armita, Tickoo Satish K, Heguy Adriana, Pappo Alberto S, Federico Sara, Dalton James, Cheung Irene Y, Ding Li, Fulton Robert, Wang Jianmin, Chen Xiang, Becksfort Jared, Wu Jianrong, Billups Catherine A, Ellison David, Mardis Elaine R, Wilson Richard K, Downing James R, Dyer Michael A
Abstract excerpt
CONTEXT: Neuroblastoma is diagnosed over a wide age range from birth through young adulthood, and older age at diagnosis is associated with a decline in survivability. OBJECTIVE: To identify genetic mutations that are associated with age at diagnosis in patients with metastatic neuroblastoma. DESIGN, SETTING, AND PATIENTS: Whole genome sequencing was performed on DNA from diagnostic tumors and their matched...
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