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Article

Mechanical loading and TGF-β change the expression of multiple miRNAs in tendon fibroblasts

27 Apr 2012

Abstract excerpt

Tendons link skeletal muscles to bones and are important components of the musculoskeletal system. There has been much interest in the role of microRNA (miRNA) in the regulation of musculoskeletal tissues to mechanical loading, inactivity, and disease, but it was unknown whether miRNA is involved in the adaptation of tendons to mechanical loading. We hypothesized that mechanical loading and transforming growth...

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PMID: 22539168
DOI: 10.1152/japplphysiol.00301.2012

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