Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrel neural progenitor cells.

eLife - 14 Oct 2020

Singhal Neel S, Bai Meirong, Lee Evan M, Luo Shuo, Cook Kayleigh R, Ma Dengke K

Abstract excerpt

Many organisms in nature have evolved mechanisms to tolerate severe hypoxia or ischemia, including the hibernation-capable Arctic ground squirrel (AGS). Although hypoxic or ischemia tolerance in AGS involves physiological adaptations, little is known about the critical cellular mechanisms underlying intrinsic AGS cell resilience to metabolic stress. Through cell survival-based cDNA expression screens in neural...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to Cytoprotection
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Mitochondrial Proton-Translocating ATPases

Share to Neural Stem Cells

Share to Sciuridae

Source

Open in PubMed Open full text

Identifiers

PMID: 33050999
DOI: 10.7554/eLife.55578
PMCID: PMC7671683

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrel neural progenitor cells.PMID 33050999Read ↗

Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell deathSemantic proximity Read ↗

The integrated stress response promotes neural stem cell survival under conditions of mitochondrial dysfunction in neurodegenerationSemantic proximity Read ↗

Functional Studies with Primary Cells Provide a System for Genome-to-Phenome Investigations in Marine Mammals.Semantic proximity Read ↗

<i>In vitro</i> and <i>in vivo</i> CRISPR-Cas9 screens reveal drivers of aging in neural stem cells of the brainSemantic proximity Read ↗

Advances in molecular biology of hibernation in mammalsSemantic proximity Read ↗

Human iPSC-derived neural stem cells with ALDH5A1 mutation as a model of succinic semialdehyde dehydrogenase deficiency.Semantic proximity Read ↗

Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations.Semantic proximity Read ↗

Integrative transcriptomic and metabolic analyses of the mammalian hibernating brain identifies a key role for succinate dehydrogenase in ischemic toleranceSemantic proximity Read ↗

Epigenomic insights into extreme longevity in the world’s oldest terrestrial animal, JonathanSemantic proximity Read ↗

Energy Flux Regulates Cell Death Induced by California Serogroup OrthobunyavirusesSemantic proximity Read ↗

A mutation in Drosophila Aldolase causes temperature-sensitive paralysis, shortened lifespan, and neurodegeneration.Semantic proximity Read ↗

Naked mole rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestylesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.