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Article

Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations.

Science (New York, N.Y.) - 9 Oct 2025

Huang Huihui, Wang Yi, Zsengeller Zsuzsanna K, Gorham Joshua M, Vemireddy Vamsidhara, Clark Amanda J, Pan Hui, Dreyfuss Jonathan M, Jotwani Vasantha, Shlipak Michael G, Sarnak Mark J, Parikh Chirag R, Thiessen-Philbrook Heather, Katz Ronit, Waikar Sushrut S, Lake Nicole J, Lek Monkol, Shi Wen, Puiu Daniela, Hong Yun Soo, Seidman Jonathan G, Arking Dan E, Parikh Samir M

Abstract excerpt

Somatically acquired mitochondrial DNA (mtDNA) mutations accumulate with age, but the mechanisms and consequences of this accumulation are poorly understood. Here we show that transient injuries induce a burst of persistent mtDNA mutations that impair resilience to future injuries. mtDNA mutations suppressed energy-intensive nucleotide metabolism. Repletion of adenosine, but not other nucleotides, restored...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40906782
DOI: 10.1126/science.adk7978
PMCID: PMC12892176

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AK4

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