Article
The three-dimensional structure of human β-endorphin amyloid fibrils.
Nature structural & molecular biology - 1 Dec 2020
Seuring Carolin, Verasdonck Joeri, Gath Julia, Ghosh Dhimam, Nespovitaya Nadezhda, Wälti Marielle Aulikki, Maji Samir K, Cadalbert Riccardo, Güntert Peter, Meier Beat H, Riek Roland
Abstract excerpt
In the pituitary gland, hormones are stored in a functional amyloid state within acidic secretory granules before they are released into the blood. To gain a detailed understanding of the structure-function relationship of amyloids in hormone secretion, the three-dimensional (3D) structure of the amyloid fibril of the human hormone β-endorphin was determined by solid-state NMR. We find that β-endorphin fibrils...
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