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Article

Pathogenic NF1 truncating mutation and copy number alterations in a dedifferentiated liposarcoma with multiple lung metastasis: a case report.

BMC medical genetics - 12 Oct 2020

Kim Yoon-Seob, Shin Sun, Jung Seung-Hyun, Chung Yeun-Jun

Abstract excerpt

BACKGROUND: Dedifferentiated liposarcoma (DDLPS), which accounts for an estimated 15-20% of liposarcomas, is a high-grade and aggressive malignant neoplasm, exhibiting a poor response to available therapeutic agents. However, genetic alteration profiles of DDLPS as well as the role of NF1 mutations have not been studied extensively. CASE PRESENTATION: The current study reports a patient presenting with rapidly...

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Identifiers

PMID: 33046013
DOI: 10.1186/s12881-020-01137-4
PMCID: PMC7552537

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