Article
Absence of association between polymorphisms in the pfcoronin and pfk13 genes and the presence of Plasmodium falciparum parasites after treatment with artemisinin derivatives in Senegal.
International journal of antimicrobial agents - 1 Dec 2020
Delandre Océane, Daffe Sokhna M, Gendrot Mathieu, Diallo Maguette N, Madamet Marylin, Kounta Mame B, Diop Moustapha N, Bercion Raymond, Sow Abdou, Ngom Papa M, Lo Gora, Benoit Nicolas, Amalvict Rémy, Fonta Isabelle, Mosnier Joel, Diawara Silman, Wade Khalifa A, Fall Mansour, Fall Khadidiatou B, Fall Bécaye, Pradines Bruno
Abstract excerpt
Due to resistance to chloroquine and sulfadoxine/pyrimethamine, treatment for uncomplicated Plasmodium falciparum malaria switched to artemisinin-based combination therapy (ACT) in 2006 in Senegal. Several mutations in the gene encoding the kelch13 helix (pfk13-propeller) have been identified as associated with in vitro and in vivo artemisinin resistance in Southeast Asia. Additionally, three mutations in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.