Article
Efficacy and safety of artemisinin-based combination therapy and the implications of Pfkelch13 and Pfcoronin molecular markers in treatment failure in Senegal.
Scientific reports - 1 Jun 2020
Diallo Mamadou Alpha, Yade Mamadou Samb, Ndiaye Yaye Die, Diallo Ibrahima, Diongue Khadim, Sy Saidou Abdoul, Sy Mouhamad, Seck Mame Cheikh, Ndiaye Mouhamadou, Dieye Baba, Gomis Jules François, Sow Djiby, Dème Awa Bineta, Badiane Aida Sadikh, Ndiaye Daouda
Abstract excerpt
In 2006, Senegal adopted artemisinin-based combination therapy (ACT) as first-line treatment in the management of uncomplicated malaria. This study aimed to update the status of antimalarial efficacy more than ten years after their first introduction. This was a randomized, three-arm, open-label study to evaluate the efficacy and safety of artemether-lumefantrine (AL), artesunate-amodiaquine (ASAQ) and...
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