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Article

Update on Head and Neck Cancer: Current Knowledge on Epidemiology, Risk Factors, Molecular Features and Novel Therapies.

Oncology - 1 Jan 2015

Pezzuto Francesca, Buonaguro Luigi, Caponigro Francesco, Ionna Franco, Starita Noemy, Annunziata Clorinda, Buonaguro Franco M, Tornesello Maria Lina

Abstract excerpt

Tobacco use and alcohol consumption are the main risk factors associated with head and neck squamous cell carcinoma (SCC) development due to their cytotoxic and mutagenic effects on the exposed epithelia of the upper aerodigestive tract. Epstein-Barr virus (EBV) and high-risk human papillomaviruses (HPVs), both encoding viral oncoproteins able to interfere with cell cycle control, have been recognized as the...

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PMID: 25967534
DOI: 10.1159/000381717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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