Article
Enlargement of interscapular brown adipose tissue in growth hormone antagonist transgenic and in growth hormone receptor gene-disrupted dwarf mice.
Experimental biology and medicine (Maywood, N.J.) - 1 Feb 2003
Li Yuesheng, Knapp Joanne R, Kopchick John J
Abstract excerpt
Growth hormone (GH) acts on adipose tissue by accelerating fat expenditure, preventing triglyceride accumulation, and facilitating lipid mobilization. To investigate whether GH is involved in the development and metabolism of interscapular brown adipose tissue (BAT), a site of nonshivering thermogenesis, we employed three lines of transgenic mice. Two of the lines are dwarf due to expression of a GH antagonist...
Topics
- Actins
- Adipocytes
- Adipose Tissue, Brown
- Animals
- Body Temperature Regulation
- Body Weight
- Carrier Proteins
- Cattle
- Dwarfism
- Female
- Gigantism
- Growth
- Growth Hormone
- Ion Channels
- Male