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Article

Aldosteronism: an immunostimulatory state precedes proinflammatory/fibrogenic cardiac phenotype.

American journal of physiology. Heart and circulatory physiology - 1 Aug 2003

Gerling Ivan C, Sun Yao, Ahokas Robert A, Wodi Linus A, Bhattacharya Syamal K, Warrington Kenneth J, Postlethwaite Arnold E, Weber Karl T

Abstract excerpt

Chronic inappropriate (relative to dietary Na+ intake) elevations in circulating aldosterone (ALDO), termed aldosteronism, are associated with remodeling of intramural arteries of the right and left heart. Lesions appear at week 4 of treatment with ALDO and 1% dietary NaCl in uninephrectomized rats (ALDOST) and include invading monocytes, macrophages and lymphocytes with intracellular evidence of oxidative and...

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Identifiers

PMID: 12860567
DOI: 10.1152/ajpheart.00113.2003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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