Article
A highly sensitive and specific real-time quantitative PCR for BRAF V600E/K mutation screening.
Scientific reports - 9 Oct 2020
Lung Jrhau, Hung Ming-Szu, Lin Yu-Ching, Jiang Yuan Yuan, Fang Yu-Hung, Lu Ming-Shian, Hsieh Ching-Chuan, Wang Chia-Siu, Kuan Feng-Che, Lu Chang-Hsien, Chen Ping-Tsung, Lin Chieh-Mo, Chou Yen-Li, Lin Chin-Kuo, Yang Tsung-Ming, Chen Fen Fen, Lin Paul Yann, Hsieh Meng-Jer, Tsai Ying Huang
Abstract excerpt
Mutations that lead to constitutive activation of key regulators in cellular processes are one of the most important drivers behind vigorous growth of cancer cells, and are thus prime targets in cancer treatment. BRAF V600E mutation transduces strong growth and survival signals for cancer cells,...
Topics
- Aged
- Carcinoma, Non-Small-Cell Lung
- Humans
- Imidazoles
- Immunohistochemistry
- Lung Neoplasms
- Male
- Middle Aged
- Mutation
- Oximes
- Protein Kinase Inhibitors