Article
Accurate detection of KRAS, NRAS and BRAF mutations in metastatic colorectal cancers by bridged nucleic acid-clamp real-time PCR.
BMC medical genomics - 11 Nov 2019
Nagakubo Yuki, Hirotsu Yosuke, Amemiya Kenji, Oyama Toshio, Mochizuki Hitoshi, Omata Masao
Abstract excerpt
BACKGROUND: Patients with metastatic colorectal cancer can benefit from anti-EGFR therapy, such as cetuximab and panitumumab. However, colorectal cancers harboring constitutive activating mutations in KRAS, NRAS and BRAF genes are not responsive to anti-EGFR therapy. To select patients for appropriate treatment, genetic testing of these three genes is routinely performed. METHODS: We applied bridged nucleic...
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