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Article

Coupling of 5S RNP rotation with maturation of functional centers during large ribosomal subunit assembly.

Nature communications - 27 Jul 2020

Micic Jelena, Li Yu, Wu Shan, Wilson Daniel, Tutuncuoglu Beril, Gao Ning, Woolford John L

Abstract excerpt

The protein composition and structure of assembling 60S ribosomal subunits undergo numerous changes as pre-ribosomes transition from the nucleolus to the nucleoplasm. This includes stable anchoring of the Rpf2 subcomplex containing 5S rRNA, rpL5, rpL11, Rpf2 and Rrs1, which initially docks onto the flexible domain V of rRNA at earlier stages of assembly. In this work, we tested the function of the C-terminal...

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Identifiers

PMID: 32719344
DOI: 10.1038/s41467-020-17534-5
PMCID: PMC7385084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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