Article
The nucle(ol)ar Tif6p and Efl1p are required for a late cytoplasmic step of ribosome synthesis.
Molecular cell - 1 Dec 2001
Senger B, Lafontaine D L, Graindorge J S, Gadal O, Camasses A, Sanni A, Garnier J M, Breitenbach M, Hurt E, Fasiolo F
Abstract excerpt
Deletion of elongation factor-like 1 (Efl1p), a cytoplasmic GTPase homologous to the ribosomal translocases EF-G/EF-2, results in nucle(ol)ar pre-rRNA processing and pre-60S subunits export defects. Efl1p interacts genetically with Tif6p, a nucle(ol)ar protein stably associated with pre-60S subunits and required for their synthesis and nuclear exit. In the absence of Efl1p, 50% of Tif6p is relocated to the...
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